Endocrine Abstracts

Factitious thyrotoxicosis secondary to Levo-thyroxine accounts for approximately 0.3% of all cases of hyperthyroidism. Although recognised as a cause of thyrotoxicosis, there are no peer-reviewed published cases of thyrotoxicosis secondary to ingestion of Tri-iodothyronine.A 23-year old lady presented to endocrine clinic with a 6-month history of palpitations, heat intolerance and tremor. She had a history of PCOS and reported difficulties with weight co...

Background: Dapagliflozin was the first SGLT2 inhibitor licensed in UK to improve glycaemic control in type 2 diabetes. Whilst it has not been studied for use in combination with GLP1 agonists the modes of action of the two therapies suggest they would be a logical therapeutic combination. We aimed to evaluate clinical experience with this regimen.Methods: Observational retrospective data was collected from electronic patient records (SCI–diabetes) ...

There is concern about the effects of long-term bisphosphonate use. A ‘treatment holiday’ is now considered after 5 years but there is no evidence as to the best way in which to monitor this.Aim: To look at the effect that a ‘treatment holiday’ has on the bone turnover marker, amino-terminal propeptide (P1NP) and bone mineral density (BMD).Methods: A retrospective case note review of 55 patients currently underg...

Introduction. Adiponectin is a novel circulating adipocyte derived protein, whose plasma concentrations paradoxically decrease with increasing fat mass. Adiponectin has been shown to improve both glucose and lipid metabolism, and circulating concentrations are inversely correlated with insulin resistance. The factors regulating adiponectin expression and secretion are poorly understood. No study has previously examined the acute post-prandial regulation of adiponectin s...

Aim: Endocrine and metabolic disorders are among the most common complications in survivors after hematopoietic stem cell transplant (HSCT). The aim of this study was to evaluate thyroid function and glucose metabolism in patients treated with HSCT.Material and methods: This was a retrospective study which included 257 adult patients (173 males and 84 females) who underwent allogeneic HSCT between 2002 and 2014 in an Irish University Hospital. All patien...

Aim: To investigate the glycaemic control of patients with T1DM before and after the introduction of CSII therapy.Methods: All patients with T1DM receiving CSII therapy for more than 6 months attending the Children’s University Hospital from 2005–2011 were included. Glycosylated haemoglobin (HbA1c) was recorded 12 and 6 months prior to starting therapy, at the time of CSII initiation and annually thereafter. Adverse events and BMI were also rec...

Objective. Globus pharyngeus is a term used to describe an abnormal throat sensation in the absence of any pathological cause. A thyroid goitre is one of the pathologies that needs to be excluded prior to making the diagnosis as it is thought that a goitre may cause similar symptoms. However, it is well recognised that postoperatively thyroidectomy patients complain of globus type symptoms.It is also recognised that most thyroidectomies are carried out in middle aged women and...

Aims: The majority of patients with Cushing's disease have pituitary microadenomas and preoperative localization can be helpful during transphenoidal surgery. Inferior petrosal sinus sampling (IPSS) of ACTH and responses to CRH may show higher levels on the side ipsilateral to the tumour, although this remains controversial. A few small studies suggested a prolactin response to CRH during IPSS. We assessed whether prolactin responses to CRH can help lateralize the microadenoma...

Background: Over the last 20 years there have been significant advances in stem cell transplantation (SCT) in adults for haematological malignancies leading to improved survival. Endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic stem cell transplant (HSCT), but data on adult transplant patients are still scarce.Methods: This is a retrospective study which included 284 adult patients (94 females and 19...

Introduction: Hypercalcaemia secondary to malignancy is rare in children. PTH-rP secreted by malignant cells increases bone resorption and renal calcium retention causing hypercalcaemia. We report a case of hypercalcaemia refractory to bisphosphonate and corticosteroid therapy, but responsive to treatment with Denosumab.Case report: A 17-year-old boy with epidermolysis bullosa presented with advanced squamous cell carcinoma of the left leg and symptomati...